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At proestrus, concomitant with the maximum rate of apoptosis, a peak in circulating levels of prolactin is observed. There is a differential expression of extracellular matrix components and integrins during the pituitary development in the embryo and during tumorigenesis in the adult. Internalization and recycling of receptor-bound gonadotropin- releasing hormone agonist in pituitary gonadotropes. Venous blood samples and hour urine specimens were obtained in normal and hypertensive pregnancies at 21 to 40 weeks of gestation. The aim of this study was to compare the effects on metabolism and immune function of reducing milk production using quinagolide a prolactin-release inhibitor or dexamethasone in feed-restricted cows. In the present study we investigated the anterior pituitary production of N-terminal prolactin -derived fragments along the estrous cycle and the involvement of estrogens in this process. The anterior pituitary gland is organized tissue comprising hormone-producing cells and folliculostellate FS cells.
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Dr. Krishna A Mutgi - Locations

Effects of cysteamine on pituitary , MTTW15 tumor, and serum prolactin levels measured by rat lymphoma cell bioassay and radioimmunoassay. There is an age-related increase in the cell population engaged in prolactin secretion, as well as an increase in the synthesis of prolactin and of the amount of prolactin secreted from individual lactotropes. Previous histomorphometric study revealed a significant increase in bone turnover in the trabecular part of the PRL-exposed long cortical bone; however, whole-bone densitometric analysis was unable to demonstrate such effect. Nevertheless, there are no reports describing how iAs affects the anterior pituitary gland. Administration of sulpiride or oestradiol released prolactin and stimulated cell proliferation in the anterior pituitary gland of adult male rats. Therefore because of its dopaminergic effect Agnus castus could be considered as an efficient alternative phytotherapeutic drug in the treatment of slight hyperprolactinaemia. In the last decade, several in vivo rat models have also been developed in our lab with a view to substantiate the in vitro findings, in order to delineate the role of pituitary hormones in the regulation of fertility of male rats.
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Krishna A. Mutgi, MD | Toledo, OH | Dermatology

We studied 10 pituitary glands of 4 women and 6 men with cardiovascular and oncological diseases. We showed that Cr VI accumulates in the pituitary and hypothalamus, and decreases serum prolactin levels in vivo but observed no effects on LH levels. The grains appeared to represent specific and high-affinity receptors for GnRH because i no pituitary cells other than gonadotropes bound the labeled ligand and ii grain development was progressively inhibited by coincubation with increasing doses of unlabeled GnRH-A. After one month follow-up he had no symptoms, visual field defect was improved and pituitary MRI showed significant shrinkage of tumor. Using goldfish as a model, we examined the global and brain- pituitary distribution of a leptin receptor lepR and examined the relationship between expression of lepR and major pituitary hormones in different pituitary regions.
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Thyrotropin-secreting pituitary adenomas are rare. Anterior pituitary hormones are central for the body homeostasis and have a fundamental role in reproductive physiology. Laboratory tests revealed; Hb: To evaluate the effect of RT, we analyzed the alteration of the endocrinological tests, neurologic abnormalities, major clinical symptoms, endocrinological changes and improvement in visual problems after RT. Cultures incubated with estradiol at different concentrations and various lengths of time showed a significant increase in gonadotropin- releasing hormone binding capacity and this increase was abrogated by cycloheximide.
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